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  • Evidence is increasing that addiction without exception is related to difficulties with the brain's reward center, specially the mesolimbic system. This the main problem regulates reward responses in getting food and sex, plus nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both after they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to shed pounds can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the those who go through it you ought to err along the side of caution and allow FDA do its job and demand some research be done so that the public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on his or her medications.

    Researchers found out that participants taking this drug for any year, dropped a few pounds within 4 weeks and have kept the weight off through the entire 56 weeks in the study. Contrave is often a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of many active ingredient, which can make them more efficient and safer.

    Combo-pilling could be the newest fad or in addition to this the newest in the future under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is now popular is the fact that by right now there are not any long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be licensed by the FDA.

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    The FDA also warned that Contrave can raise blood pressure level and heartbeat and must stop used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients having a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.

    The most common side effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.